Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis

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J Qiu, T Wei. Immediate or postponed intervention for infected necrotizing pancreatitis. New England Journal of Medicine. 2022. doi:10.1056/nejmc2117813 PMID:35081292.
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T Saito, T Fujisawa, T Ogura, M Kuwatani, H Ohyama…. Immediate or On-Demand Endoscopic Necrosectomy for Necrotizing Pancreatitis: A Randomized Controlled Trial (WONDER-01). Gastroenterology. 2026. doi:10.1053/j.gastro.2026.01.034 PMID:41720198.
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SJ Mahapatra, PK Garg. Navigating the stormy sea of infected necrotizing pancreatitis: are we there yet? well almost!. Gastroenterology. 2022. doi:10.1053/j.gastro.2022.06.082 PMID:35793777.
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PK Garg, VP Singh. Organ failure due to systemic injury in acute pancreatitis. Gastroenterology. 2019.
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G Grajales-Figueroa…. Increased mortality from extrapancreatic infections in hospitalized patients with acute pancreatitis. Gastroenterology …. 2019. doi:10.1155/2019/2789764 PMID:30944558.
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C Rood. Lipotoxicity and Cytokine Storm in Severe Acute Pancreatitis and COVID-19. Aliment Pharmacol Ther. 2015. doi:10.1053/j.gastro.2020.07.014 PMID:32682765.
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L Ke, G Li, W Mao, G Doig, T Chen, C Li, C Qu…. Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial. Intensive Care …. 2025. doi:10.1007/s00134-025-08020-x PMID:40658249.
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L Ke, J Zhou, W Mao, T Chen, Y Zhu, X Pan…. Immune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial. Intensive Care …. 2022. doi:10.1007/s00134-022-06745-7 PMID:35713670.
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M Feng, F Luo, L Huang, K Li, Z Chen, H Li…. Rheum palmatum L. and Salvia miltiorrhiza Bge. Alleviates Acute Pancreatitis by Regulating Th17 Cell Differentiation: An Integrated Network Pharmacology Analysis …. Chinese Journal of …. 2024. doi:10.1007/s11655-023-3559-6 PMID:37861962.
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X Chen, X Chen, D Yan, N Zhang, W Fu, M Wu…. GV-971 prevents severe acute pancreatitis by remodeling the microbiota-metabolic-immune axis. Nature …. 2024. doi:10.1038/s41467-024-52398-z PMID:39333064.
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G Li, L Liu, T Lu, Y Sui, C Zhang, Y Wang…. Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis. Nature …. 2023. doi:10.21203/rs.3.rs-2462664/v2.
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X Chen, Z Lin, Y Chen, C Lin. C-reactive protein/lymphocyte ratio as a prognostic biomarker in acute pancreatitis: a cross-sectional study assessing disease severity. International Journal of Surgery. 2024.
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JJ Litewka, MD Szopa, K Fryt, MA Jakubowska…. Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis. Cell Death & …. 2025. doi:10.1038/s41419-025-07881-w PMID:40715042.
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DRJ Wolbrink, E Kolwijck, J Ten Oever…. Management of infected pancreatic necrosis in the intensive care unit: a narrative review. Clinical Microbiology …. 2020.
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L Deng, Z Chen, T Jin, F Cai, Y He, Y Shen, S Zhang…. Traditional Chinese medicine Chaiqinchengqi decoction for patients with acute pancreatitis: A randomized clinical trial. Phytomedicine. 2025. doi:10.1016/j.phymed.2025.156393 PMID:39879706.
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S Liu, Q Wang, W Luo, L Huang, L Li, Y Wu, W Cai…. Histones are critical toxic factors in gut lymph of severe acute pancreatitis: Neutralization by baicalin and baicalein for protection. Phytomedicine. 2025. doi:10.1016/j.phymed.2025.156474 PMID:39954616.
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Q Zhou, X Tao, F Guo, Y Wu, D Deng, L Lv, D Dong…. Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases. BMC medicine. 2023. doi:10.1186/s12916-023-02997-2 PMID:37635214.
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F Chen, K Xu, Y Han, J Ding, J Ren, W Qian…. Hydrostatic pressure induces mitochondrial oxidative stress and mtDNA-mediated cGAS–STING activation in acute pancreatitis. Free Radical Biology …. 2025. doi:10.1016/j.freeradbiomed.2025.11.031 PMID:41260392.
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S Lyu, S Liu, X Guo, Y Zhang, Z Liu, S Shi, W Li, J Pei…. hP-MSCs attenuate severe acute pancreatitis in mice via inhibiting NLRP3 inflammasome-mediated acinar cell pyroptosis. Apoptosis. 2024. doi:10.1007/s10495-024-01946-5 PMID:38625481.
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GC Harewood. Endoscopic necrosectomy: A WONderful approach, but when and how often?. Gastrointestinal Endoscopy. 2025. doi:10.1016/j.gie.2024.12.004 PMID:40345746.
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W Zhou, S Dong, Z Chen, X Li, W Jiang. New challenges for microRNAs in acute pancreatitis: progress and treatment. Journal of Translational …. 2022. doi:10.1186/s12967-022-03338-2 PMID:35509084.
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M Vornhülz, S Sirtl, Y Xu, S Klauss…. Common practice of percutaneous drainage in necrotising pancreatitis—A multicentre retrospective study (DRACULA). United European …. 2025. doi:10.1002/ueg2.70133 PMID:41137746.
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NDE Thierens, IE Demir. How safe are opioids in the early phase of acute pancreatitis?. United European Gastroenterology …. 2024. doi:10.1002/ueg2.12545 PMID:38334426.
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W Mao, K Li, J Zhou, M Chen, B Ye, G Li…. Prediction of infected pancreatic necrosis in acute necrotizing pancreatitis by the modified pancreatitis activity scoring system. United European …. 2023. doi:10.1002/ueg2.12353 PMID:36579414.
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C Patoni, S Bunduc, L Frim, DS Veres…. Low molecular weight heparin decreases mortality and major complication rates in moderately severe and severe acute pancreatitis–a systematic review and meta …. Frontiers in …. 2023. doi:10.3389/fmed.2023.1241301 PMID:38020092.
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Y Lv, J Zhang, T Yang, J Sun, J Hou, Z Chen…. Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for developing new-onset diabetes after acute pancreatitis: a multicenter retrospective cohort …. Frontiers in …. 2022. doi:10.3389/fendo.2022.903731 PMID:35692404.
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Z Sun, Y Fu, J Li, B Liu, X Hong, C Lin, D Shen…. Prediction of infected pancreatic necrosis in patients with acute necrotizing pancreatitis based on ensemble machine learning model. World Journal of …. 2025. doi:10.1186/s13017-025-00642-2 PMID:40770755.
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XR Fan, Y Huang, Y Su, SJ Chen…. Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments. World Journal of …. 2023. doi:10.3748/wjg.v29.i30.4642 PMID:37662862.
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B Zhao, W Sun, Y Wang, L Ma, M Gui, J Li, X Yu…. High-dose intravenous vitamin C reduce C-reactive protein levels, fluid retention, and APACHE II scores in patients with moderately severe acute pancreatitis …. Annals of Intensive …. 2025. doi:10.1186/s13613-025-01437-z PMID:40091112.
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HT Long, VV Hùng, NH Vân, NM Khiêm. 31. NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA VIÊM TỤY HOẠI TỬ ĐƯỢC ĐIỀU TRỊ BẰNG CAN THIỆP DẪN LƯU QUA DA. Tạp chí Y học Cộng đồng. 2024. doi:10.52163/yhc.v65i3.1082.
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L Zhang, J Shi, D Du, N Niu, S Liu, X Yang, P Lu…. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. …. 2022. doi:10.1016/j.ebiom.2022.103959 PMID:35339899.
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金秋，杨婧，马红琳，李苹菊…. 不同评分系统预测高脂血症性急性胰腺炎严重程度及预后的价值分析.. Journal of Clinical …. 2022.
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SH Loosen, T Essing, M Jördens…. Current epidemiological trends and in-hospital mortality of acute pancreatitis in Germany: a systematic analysis of standardized hospital discharge data between 2008 …. Zeitschrift für …. 2022. doi:10.1055/a-1682-7621 PMID:34820807.
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S Güler, D Üçöz Kocaşaban, S Coşkun Yaş…. Relationship of Lactate-Albumin Ratio with Disease Severity in Patients with Acute Pancreatitis. Bratislava Medical …. 2025. doi:10.1007/s44411-025-00019-6.
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Y Wu, Y Pan. Association between magnesium sulfate administration and short-term mortality in acute pancreatitis patients admitted to the ICU: a retrospective cohort study based …. Magnesium Research. 2025. doi:10.1684/mrh.2025.0544 PMID:40626736.
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L Rudroff, G Beyer. Akute Pankreatitis. Die Innere Medizin. 2026. doi:10.1159/000424648.
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MT Enaohwo, OC Orororo…. Ethanol Extracts of Justicia carnea Leaves Mitigate Pancreatic Oxidative Stress and Preserve Islet Glucagon Expression in TNBS-treated Mice. Journal of …. 2026.
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ТЮ Іванець - 2025. Визначення маркерів прогнозування тяжкості перебігу гострого панкреатиту та некротичних змін паренхіми підшлункової залози. 2025. 2025.
МВ Коротя - 2025. Секвестрнекректомія в хірургічному лікуванні хворих на інфікований некротичний панкреатит. 2025. 2025.
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